Immunization against LHRH in ewes for suppressing reproductive functions and possibilities of using PMSG or LHRH in restoring reproductive functions in LHRH immunized ewes

Effect of active immunization against LHRH or LH in boars: reproductive consequences and performance traits.

Forty crossbred boars were equally divided into eight groups at birth. Four groups were immunized (200 micrograms/boar) at 12 wk of age against either luteinizing hormone-releasing hormone (LHRH) conjugated to human serum globulin (LHRH-hSG) in complete Freund's adjuvant (CFA), LHRH-hSG in muramyldipeptide adjuvant (PEP), procine luteinizing hormone (LH) conjugated to hSG (pLH-hSG) in CFA or ov...

GnRH or eCG treatment fails to restore reproductive function in GnRH immunized ewes.

This study was designed to evaluate the potential of using eCG or GnRH in restoring reproductive functions in GnRH immunized ewes. Thirty-three multiparous Kivircik ewes were randomly assigned into either control group (n=11) or immunization group (n=22). Ewes were immunized against GnRH by injecting with a cocktail of ovalbumin-LHRH-7 (ovalbumin-GnRH-7) and thioredoxin-LHRH-7 (thioredoxin-GnRH...

Extrapituitary action of LHRH and LHRH-like substance in the testes.

LHRH antagonists vs LHRH agonists: which is more beneficial in prostate cancer therapy?

Crawford and Hou[1] review the data on luteinizing hormone-releasing hormone (LHRH) antagonists in prostate cancer. They describe the results of a phase III trial comparing monthly degarelix to monthly leuprolide in men with advanced prostate cancer. Degarelix treatment was associated with a more rapid decline of serum testosterone, and was not associated with an initial surge of serum testoste...

Immunization of sheep against GnRH early in life: effects on reproductive function and hormones in ewes.

Groups of Merino ewe lambs were immunized against GnRH either soon after birth (prepubertal) or around puberty (peripubertal) with a prototype commercial preparation and were studied over the following 2 years to determine the long-term effects on reproductive development, function and hormone concentrations. At least 60% of the GnRH-immunized ewes in either treatment group did not experience o...